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KMID : 0369820120420050285
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Jorunal of Korean Pharmaceutical Sciences
2012 Volume.42 No. 5 p.285 ~ p.291
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Dissolution properties of control released solid dispersion of carvedilol with HPMC and Eudragit RS
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Shim Jung-Bo
Kim Min-Jeong
Kim Seul-Ji
Kang Su-Ji
Lee Ji-Hye
Kim Hyeong-Seok
Lee Dong-Won
Khang Gil-Son
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Abstract
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In this study, solid dispersion for carvedilol was prepared by using spray-drying method. Solid dispersions were formulated with carvedilol and Eudragit RS and hydroxypropyl methylcellulose to control the dissolution rates of carvedilol. Scanning electron microscope was used to analyze surface of solid dispersion samples. Differential scanning calorimetry and powder X-ray diffraction were used to analyze the crystallinity of solid dispersions. Fourier transform infrared spectroscopy was used to analyze the change in chemical structure of solid dispersions. The release behavior of solid dispersion analyzed at simulated gastric fluid (pH 1.2) in in vitro study. The dissolution rate of carvedilol was higher than active pharmaceutical ingredient. In conclusion, we can control the dissolution rate by solid dispersion using biomedical polymers.
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KEYWORD
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Carvedilol, Eudragit RS, HPMC, Solid dispersion, Spray dry
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